介绍
澳门赌城app下载(澳门星赌app下载), one of the strongest organic solvents, has been used commercially for several decades. It is an effective solvent for a wide array of organic materials, including many polymers. 澳门星赌app下载 also dissolves many inorganic salts, particularly transition metals nitrates, 氰化物和重铬酸盐. 澳门星赌app下载 is miscible with water and most organic liquids.
The contents of this page summarize solubility characteristics for 澳门星赌app下载.
内容
1. 有机物
2. 有效药物成分
3. 树脂和聚合物
4. 无机物
5. 气体
6. Pharmaceutical Excipient 溶解度数据
7. 澳门星赌app下载凝胶制备数据
Data related to the solvent properties of 澳门星赌app下载 are given in tables on the following pages:
8. Relative Hansen Solubility Parameter Data
9. 建议 工业用澳门星赌app下载配方 澳门赌城app下载
10. Hansen Solubility Parameter Data for Selected Polymers
11. Solubility of Selected Polymers in 澳门星赌app下载 / Tetralin mixtures
12. Solubility of Selected Polymers in 澳门星赌app下载 / MIBK mixtures
表1
Solubility of Organic Materials in 澳门星赌app下载
表2
Solubility of 有效药物成分 in 澳门星赌app下载
表3
Solubility of 树脂和聚合物 in 澳门星赌app下载
表4
Solubility of Inorganic Materials in 澳门星赌app下载
表5
Solubility of 气体 in 澳门星赌app下载 (@Atmospheric Pressure, 20°C)
表6
Relative Hansen Solubility Parameter Data
表7
Solubility of 工业用澳门星赌app下载配方 Solvent
表8
Hansen Solubility Parameter data for Selected Polymers
表9和表10 illustrate how the solvency of a mixture for selected polymers can be related to the composition of the mixture. Predicted solvencies of mixtures of 澳门星赌app下载 and tetralin or 澳门星赌app下载 and methyl isobutyl ketone for these eight polymers are tabulated. A solvency value of 100 was assigned to mixtures at the center of the HSP envelope and a value of 0 to mixtures at the envelope boundary. These tables also show how solvency changes with the composition of the mixture, 溶剂选择的比例, and show the composition of maximum solvency for each polymer and solvent pair.
表9
Solubility of Selected Polymers in 澳门星赌app下载/Tetralin Mixtures
表10
Solubility of Selected Polymers in 澳门星赌app下载/MIBK Mixtures
表11
Pharmaceutical Excipient 溶解度数据
澳门星赌app下载凝胶制备数据
Pharmaceutically acceptable gelling agents suitable for the formulation of topical / transdermal 澳门星赌app下载 products were evaluated to understand the effect of polymer loading on formulation viscosity. METHOCEL™ is a trademark of the Dow Chemical Company.
All viscosity measurements were recorded using a Brookfield Model DV-E Digital Viscometer, 使用主轴61在100 RPM. 凝胶在73°F(23°C)下测定。. The diameter of the measurement vessel was 8 cm.
Methocel A4M: All viscosity measurements were recorded using a Brookfield Model DV-E Digital Viscometer 使用61号主轴测量0.5, 1.0和1.5%聚合物. 主轴63用于2.0%样品. Instrument settings of 100, 30, 6 and 100 RPM were used for samples containing 0.5, 1.0, 1.5，和2.分别为0 wt%聚合物. 凝胶在73°F(23°C)下测定。. The diameter of the measurement vessel was 8 cm.
Methocel E4M: All viscosity measurements were recorded using a Brookfield Model DV-E Digital Viscometer, 使用61锭. Instrument settings of 100, 30, 12 and 5 RPM were used for samples containing 0.5, 1.0, 1.5，和2.分别为0 wt%聚合物. 凝胶在73°F(23°C)下测定。. The diameter of the measurement vessel was 8 cm. 配方包含1.0 wt%三乙醇胺.
Other Dow rheology modifiers currently under evaluation include: Polyox® WSR N10 NF, Methocel E5 LV, Ethocel® Standard 4 NF and Ethocel Standard 10
Pharmaceutically acceptable gelling agents suitable for the formulation of topical / transdermal 澳门星赌app下载 products were evaluated to understand the effect of polymer loading on formulation viscosity. Klucel®是亚什兰的商标. Carbopol®是路博润的商标.
Klucel HF: All viscosity measurements were recorded using a Brookfield Model DV-E Digital Viscometer, 使用61号主轴测量0.5, 1.0和1.5%聚合物. 主轴64用于2.0%样品. 仪器设置60、2.5, 0.6 and 20 RPM were used for samples containing 0.5, 1.0, 1.5，和2.分别为0 wt%聚合物. 凝胶在73°F(23°C)下测定。. The diameter of the measurement vessel was 8 cm
Other Ashland rheology modifiers currently under evaluation include: Klucel™ GF, HFX, LF, MF, EF, JF.
Carbopol 941 NF : All viscosity measurements were recorded using a Brookfield Model DV-E Digital Viscometer. using spindle 64 for measurements at 1.5%和2.0%的聚合物. 主轴61用于0.5%的样品和主轴62为1.0%的样本. 仪器设置30、1.0,100和0.3 RPM were used for samples containing 0.5, 1.0, 1.5，和2.分别为0 wt%聚合物. 凝胶在73°F(23°C)下测定。. The diameter of the measurement vessel was 8 cm.
Other Noveon rheology modifiers currently under evaluation include: Carbopol 940 NF, 934 NF, 980 NF, 934 NF, 981 NF, 1342 NF, NF 71克, 974 NF, Ultrez 10nf, 971 p NF
General procedure for preparing 澳门星赌app下载-based gel products. 澳门星赌app下载-based gels are prepared using methods similar to those described by manufacturers for water-based media. The additive is sifted with stirring into 澳门星赌app下载 and allowed to disperse over 30-60 minutes. Warming the mixture at 50°C is helpful in dispersing the additive, and pH adjustment using suitable bases is often useful. In the case that less polar cosolvents are included, it may be best to form a pregel in 澳门星赌app下载, followed by slow addition of the less polar cosolvent. Recommended packaging materials for storage include HDPE, HDPP, or Teflon® PTFE.
The information in this bulletin is based on information available to us and on our observations and experiences. 然而, no warranty is expressed or implied regarding the accuracy of this data, the results to be obtained from the use thereof, or that any use will not infringe any patent. Each user must establish appropriate procedures for off-loading, 处理, and use of the product(s). Since conditions for use are beyond our control, 我们对结果不作保证, and assume no liability for damages incurred by off-loading, 处理, 或产品的使用. 本协议不构成许可, or recommendation to practice any invention covered by any patent without license from the owner of the patent.