取代NMP

N-Methylpyrollidone (NMP) serves an important function as a powerful solvent in numerous applications including those in microelectronics, 澳门星赌app下载, 药品, and industrial cleaning. Though NMP’s performance is proven in these industries, safe handling and worker exposure is of growing concern given NMP’s toxicological hazards. NMP is a confirmed reproductive toxin which has already led to strict restrictions on its use and labeling in both the US and the EU.

Dimethyl Sulfoxide (澳门星赌app下载) and NMP are nearly alike in terms performance and physical properties; both are water miscible, highly polar solvents with high flashpoints, 低蒸汽压, and comparable solvent parameters. Where 澳门星赌app下载 differs from NMP is in its safety profile; 澳门星赌app下载 is non-toxic by all routes of exposure, 可生物降解的, 和安全的. This combination of safety and performance makes 澳门星赌app下载 the ideal candidate for NMP replacement.

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Applications in which NMP is used Include:

• 微电子学 – Photoresist Film Removal 
• Agrichemical 公式tion 
• 制药
• 油漆和涂料
• 油漆脱衣舞娘
• 金属清洗
• 聚合物生产 
• 溶剂萃取 
• 芳香萃取 

The data below serves to highlight key points of comparison between NMP and 澳门星赌app下载.

Is 澳门星赌app下载 safer to use than NMP?

是的. 澳门星赌app下载 is considerably safer to use than NMP, as shown in table two. Regardless of exposure type, 澳门星赌app下载 has favorable safety data to support its use.

The main worry associated with NMP is its reproductive toxicity. This issue is driving regulatory action in both the EU and the US, and is restricting its use in some applications.

在美国, the EPA recently evaluated NMP under the amended Toxic Substances Control Act (TSCA) and concluded the Final Risk Evaluation (December 2020). The results of the final risk evaluation determined that NMP exposes workers and consumers to unreasonable risks in 26 out of 37 conditions of use. These conditions include an array of use cases from cleaning applications to pharmaceutical and agrichemical applications. The EPA is in the process of determining risk management actions that may result in use restrictions.

皮肤渗透

There is some concern that solvents like 澳门星赌app下载 and NMP can penetrate skin. In fact, both solvents do penetrate skin to approximately the same degree (figure 1). The use of appropriate gloves is always a good idea when handling solvents. For 澳门星赌app下载, Ansell TNT® Blue disposable nitrile gloves (VWR catalog # 32889-888) are recommended.

Although it has many solvent properties that resemble NMP, 澳门星赌app下载 is safer to work with (oral, 真皮, 吸入暴露).

Will 澳门星赌app下载 work as a substitute for NMP?

Both solvents are very polar materials, with high boiling points and 低蒸汽压. 澳门星赌app下载 has a smaller molar volume. Both are totally water soluble.

Although it is difficult to predict exactly how solvents will perform when one is directly substituted for another in an application, in most cases 澳门星赌app下载 and NMP will work very similarly. 公式tion with suitable cosolvents / additives can often make up for any differences in cleaning performance.

How Do their physical properties compare?

The basic physical properties of 澳门星赌app下载 and NMP are nearly alike. Both have high flashpoints, 低蒸汽压, and have comparable solvent parameters.

One difference worth noting is the relatively high freezing point of 澳门星赌app下载 (18.5°C). When necessary, 澳门星赌app下载 can be formulated to depress the mixture freezing point. Suitable drum-warming equipment is also readily available.